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KMID : 0043320130360101198
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Archives of Pharmacal Research
2013 Volume.36 No. 10 p.1198 ~ p.1203
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Two new neolignans from Patrinia scabra with potent cytotoxic activity against HeLa and MNK-45 cells
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Di Lei
Yan Guo Qing
Wang Ling Yu
Ma Wei
Wang Kai Jin
Li Ning
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Abstract
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Two new neolignans, patrineolignan A (1) and patrineolignan B (2), together with seven known lignans, were isolated from the 90 % aqueous EtOH extract of the roots of Patrinia scabra. Their structures were elucidated on the basis of spectroscopic data (HRESIMS, IR, 1D and 2D NMR) and comparison with literature data. The two new neolignans were evaluated in vitro for cytotoxic properties against human cervical carcinoma HeLa cell line and gastric carcinoma MNK-45 cell line using the microculture tetrazolium assay, and both 1 and 2 exhibited strongly cytotoxic activity against the two tumor cell lines.
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KEYWORD
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Patrinia scabra, Neolignan, Lignan, Cytotoxic activity, HeLa cell, MNK-45 cell
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